Mixed effect model autocorrelation - It is a linear mixed model, with log-transformed OM regressed on marsh site (categorical), marsh type (categorical), soil category (categorical), depth (numerical, based on ordinal depth ranges), and the interaction between depth and marsh type; marsh site effects are modeled as random, on which the ICAR spatial autocorrelation structure is ...

 
Generalized additive models were flrst proposed by Hastie and Tibshirani (1986, 1990). These models assume that the mean of the response variable depends on an additive pre-dictor through a link function. Like generalized linear models (GLMs), generalized additive models permit the response probability distribution to be any member of the .... Unlined mesh full coverage plunge bra

May 22, 2018 · 10.8k 7 39 67. 1. All LMMs correspond to a multivariate normal model (while the converse is not true) with a structured variance covariance matrix, so "all" you have to do is to work out the marginal variance covariance matrix for the nested random-effect model and fit that - whether gls is then able to parameterize that model is then the next ... I am seeking advice on how to effectively eliminate autocorrelation from a linear mixed model. My experimental design and explanation of fixed and random factors can be found here from an earlier question I asked: Crossed fixed effects model specification including nesting and repeated measures using glmm in RSubject. Re: st: mixed effect model and autocorrelation. Date. Sat, 13 Oct 2007 12:00:33 +0200. Panel commands in Stata (note: only "S" capitalized!) usually accept unbalanced panels as input. -glamm- (remember the dashes!), which you can download from ssc (by typing: -ssc install gllamm-), allow for the option cluster, which at least partially ...This is what we refer to as “random factors” and so we arrive at mixed effects models. Ta-daa! 6. Mixed effects models. A mixed model is a good choice here: it will allow us to use all the data we have (higher sample size) and account for the correlations between data coming from the sites and mountain ranges.Jul 1, 2021 · Mixed Effects Models - Autocorrelation. Jul. 1, 2021 • 0 likes • 171 views. Download Now. Download to read offline. Education. Lecture 19 from my mixed-effects modeling course: Autocorrelation in longitudinal and time-series data. Scott Fraundorf Follow. Models all contained the same fixed effects, were compared using AIC, and were fitted by REML (to allow comparison of different correlation structures by AIC). I'm using the R package nlme and the gls function. Question 1. The GLS models' residuals still display almost identical cyclical patterns when plotted against time.Spatial and temporal autocorrelation can be problematic because they violate the assumption that the residuals in regression are independent, which causes estimated standard errors of parameters to be biased and causes parametric statistics no longer follow their expected distributions (i.e. p-values are too low).You need to separately specify the intercept, the random effects, the model matrix, and the spde. The thing to remember is that the components of part 2 of the stack (multiplication factors) are related to the components of part 3 (the effects). Adding an effect necessitates adding another 1 to the multiplication factors (in the right place).It is a linear mixed model, with log-transformed OM regressed on marsh site (categorical), marsh type (categorical), soil category (categorical), depth (numerical, based on ordinal depth ranges), and the interaction between depth and marsh type; marsh site effects are modeled as random, on which the ICAR spatial autocorrelation structure is ...Dec 11, 2017 · Mixed-effect linear models. Whereas the classic linear model with n observational units and p predictors has the vectorized form. where and are design matrices that jointly represent the set of predictors. Random effects models include only an intercept as the fixed effect and a defined set of random effects. Apr 15, 2016 · 7. I want to specify different random effects in a model using nlme::lme (data at the bottom). The random effects are: 1) intercept and position varies over subject; 2) intercept varies over comparison. This is straightforward using lme4::lmer: lmer (rating ~ 1 + position + (1 + position | subject) + (1 | comparison), data=d) > ... You need to separately specify the intercept, the random effects, the model matrix, and the spde. The thing to remember is that the components of part 2 of the stack (multiplication factors) are related to the components of part 3 (the effects). Adding an effect necessitates adding another 1 to the multiplication factors (in the right place).Is it accurate to say that we used a linear mixed model to account for missing data (i.e. non-response; technology issues) and participant-level effects (i.e. how frequently each participant used ...Gamma mixed effects models using the Gamma() or Gamma.fam() family object. Linear mixed effects models with right and left censored data using the censored.normal() family object. Users may also specify their own log-density function for the repeated measurements response variable, and the internal algorithms will take care of the optimization.Aug 9, 2023 · Arguments. the value of the lag 1 autocorrelation, which must be between -1 and 1. Defaults to 0 (no autocorrelation). a one sided formula of the form ~ t, or ~ t | g, specifying a time covariate t and, optionally, a grouping factor g. A covariate for this correlation structure must be integer valued. When a grouping factor is present in form ... 3.1 The nlme package. nlme is a package for fitting and comparing linear and nonlinear mixed effects models. It let’s you specify variance-covariance structures for the residuals and is well suited for repeated measure or longitudinal designs. a random effect for the autocorrelation. After introducing the extended mixed-effect location scale (E-MELS), ... mixed-effect models that have been, for example, combined with Lasso regression (e ...Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2).a random effect for the autocorrelation. After introducing the extended mixed-effect location scale (E-MELS), ... mixed-effect models that have been, for example, combined with Lasso regression (e ... Dear fellow Matlab users, Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from c...You should try many of them and keep the best model. In this case the spatial autocorrelation in considered as continous and could be approximated by a global function. Second, you could go with the package mgcv, and add a bivariate spline (spatial coordinates) to your model. This way, you could capture a spatial pattern and even map it.c (Claudia Czado, TU Munich) – 11 – Likelihood Inference for LMM: 1) Estimation of β and γ for known G and R Estimation of β: Using (5), we have as MLE or weighted LSE of βSubject. Re: st: mixed effect model and autocorrelation. Date. Sat, 13 Oct 2007 12:00:33 +0200. Panel commands in Stata (note: only "S" capitalized!) usually accept unbalanced panels as input. -glamm- (remember the dashes!), which you can download from ssc (by typing: -ssc install gllamm-), allow for the option cluster, which at least partially ...I have a dataset of 12 days of diary data. I am trying to use lme to model the effect of sleep quality on stress, with random intercept effects of participant and random slope effect of sleep quality. I am not particularly interested in asking whether there was change over time from diaryday 1 to 12, just in accounting for the time variable.c (Claudia Czado, TU Munich) – 11 – Likelihood Inference for LMM: 1) Estimation of β and γ for known G and R Estimation of β: Using (5), we have as MLE or weighted LSE of β Dec 24, 2014 · Is it accurate to say that we used a linear mixed model to account for missing data (i.e. non-response; technology issues) and participant-level effects (i.e. how frequently each participant used ... Arguments. the value of the lag 1 autocorrelation, which must be between -1 and 1. Defaults to 0 (no autocorrelation). a one sided formula of the form ~ t, or ~ t | g, specifying a time covariate t and, optionally, a grouping factor g. A covariate for this correlation structure must be integer valued. When a grouping factor is present in form ...See full list on link.springer.com It is evident that the classical bootstrap methods developed for simple linear models should be modified to take into account the characteristics of mixed-effects models (Das and Krishen 1999). In ...The advantage of mixed effects models is that you can also account for non-independence among "slopes". As you said, you may assume more similarity from fish within tanks, but - e.g. - over time ... Mixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5].Aug 13, 2021 · 1 Answer. In principle, I believe that this would work. I would suggest to check what type of residuals are required by moran.test: deviance, response, partial, etc. glm.summaries defaults to deviance residuals, so if this is what you want to test, that's fine. But if you want the residuals on the response scale, that is, the observed response ... 3. MIXED EFFECTS MODELS 3.1 Overview of mixed effects models When a regression contains both random and fixed effects, it is said to be a mixed effects model, or simply, a mixed model. Fixed effects are those with which most researchers are familiar. Any covariate that is assumed to have the same effect for all responses throughout thea combination of both models (ARMA). random effects that model independence among observations from the same site using GAMMs. That is, in addition to changing the basis as with the nottem example, we can also add complexity to the model by incorporating an autocorrelation structure or mixed effects using the gamm() function in the mgcv package It is a linear mixed model, with log-transformed OM regressed on marsh site (categorical), marsh type (categorical), soil category (categorical), depth (numerical, based on ordinal depth ranges), and the interaction between depth and marsh type; marsh site effects are modeled as random, on which the ICAR spatial autocorrelation structure is ...in nlme, it is possible to specify the variance-covariance matrix for the random effects (e.g. an AR (1)); it is not possible in lme4. Now, lme4 can easily handle very huge number of random effects (hence, number of individuals in a given study) thanks to its C part and the use of sparse matrices. The nlme package has somewhat been superseded ...How is it possible that the model fits perfectly the data while the fixed effect is far from overfitting ? Is it normal that including the temporal autocorrelation process gives such R² and almost a perfect fit ? (largely due to the random part, fixed part often explains a small part of the variance in my data). Is the model still interpretable ?Arguments. the value of the lag 1 autocorrelation, which must be between -1 and 1. Defaults to 0 (no autocorrelation). a one sided formula of the form ~ t, or ~ t | g, specifying a time covariate t and, optionally, a grouping factor g. A covariate for this correlation structure must be integer valued. When a grouping factor is present in form ...We conducted a small simulation study to investigate whether an extension of the mixed-effect model that considers between-person differences in the Level 1 variance and the autocorrelation (i.e., the E-MELS) yields more precise forecasts than a standard longitudinal mixed-effect model.May 22, 2018 · 10.8k 7 39 67. 1. All LMMs correspond to a multivariate normal model (while the converse is not true) with a structured variance covariance matrix, so "all" you have to do is to work out the marginal variance covariance matrix for the nested random-effect model and fit that - whether gls is then able to parameterize that model is then the next ... I am seeking advice on how to effectively eliminate autocorrelation from a linear mixed model. My experimental design and explanation of fixed and random factors can be found here from an earlier question I asked: Crossed fixed effects model specification including nesting and repeated measures using glmm in RChapter 10 Mixed Effects Models. Chapter 10. Mixed Effects Models. The assumption of independent observations is often not supported and dependent data arises in a wide variety of situations. The dependency structure could be very simple such as rabbits within a litter being correlated and the litters being independent.1 Answer. In principle, I believe that this would work. I would suggest to check what type of residuals are required by moran.test: deviance, response, partial, etc. glm.summaries defaults to deviance residuals, so if this is what you want to test, that's fine. But if you want the residuals on the response scale, that is, the observed response ...The code below shows how the random effects (intercepts) of mixed models without autocorrelation terms can be extracted and plotted. However, this approach does not work when modelling autocorrelation in glmmTMB. Use reproducible example data from this question: glmmTMB with autocorrelation of irregular timesMixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5].Therefore, even greater sampling rates will be required when autocorrelation is present to meet the levels prescribed by analyses of the power and precision when estimating individual variation using mixed effect models (e.g., Wolak et al. 2012; Dingemanse and Dochtermann 2013)a combination of both models (ARMA). random effects that model independence among observations from the same site using GAMMs. That is, in addition to changing the basis as with the nottem example, we can also add complexity to the model by incorporating an autocorrelation structure or mixed effects using the gamm() function in the mgcv packageAug 9, 2023 · Arguments. the value of the lag 1 autocorrelation, which must be between -1 and 1. Defaults to 0 (no autocorrelation). a one sided formula of the form ~ t, or ~ t | g, specifying a time covariate t and, optionally, a grouping factor g. A covariate for this correlation structure must be integer valued. When a grouping factor is present in form ... Aug 8, 2018 · 3. MIXED EFFECTS MODELS 3.1 Overview of mixed effects models When a regression contains both random and fixed effects, it is said to be a mixed effects model, or simply, a mixed model. Fixed effects are those with which most researchers are familiar. Any covariate that is assumed to have the same effect for all responses throughout the Chapter 10 Mixed Effects Models. Chapter 10. Mixed Effects Models. The assumption of independent observations is often not supported and dependent data arises in a wide variety of situations. The dependency structure could be very simple such as rabbits within a litter being correlated and the litters being independent. Models all contained the same fixed effects, were compared using AIC, and were fitted by REML (to allow comparison of different correlation structures by AIC). I'm using the R package nlme and the gls function. Question 1. The GLS models' residuals still display almost identical cyclical patterns when plotted against time.Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2).In the present article, we suggested an extension of the mixed-effects location scale model that allows a researcher to include random effects for the means, the within-person residual variance, and the autocorrelation.Yes. How can glmmTMB tell how far apart moments in time are if the time sequence must be provided as a factor? The assumption is that successive levels of the factor are one time step apart (the ar1 () covariance structure does not allow for unevenly spaced time steps: for that you need the ou () covariance structure, for which you need to use ...a random effect for the autocorrelation. After introducing the extended mixed-effect location scale (E-MELS), ... mixed-effect models that have been, for example, combined with Lasso regression (e ... Oct 11, 2022 · The code below shows how the random effects (intercepts) of mixed models without autocorrelation terms can be extracted and plotted. However, this approach does not work when modelling autocorrelation in glmmTMB. Use reproducible example data from this question: glmmTMB with autocorrelation of irregular times Here's a mixed model without autocorrelation included: cmod_lme <- lme(GS.NEE ~ cYear, data=mc2, method="REML", random = ~ 1 + cYear | Site) and you can explore the autocorrelation by using plot(ACF(cmod_lme)) .3. MIXED EFFECTS MODELS 3.1 Overview of mixed effects models When a regression contains both random and fixed effects, it is said to be a mixed effects model, or simply, a mixed model. Fixed effects are those with which most researchers are familiar. Any covariate that is assumed to have the same effect for all responses throughout theFeb 3, 2021 · I have temporal blocks in my data frame, so I took the effect of time dependency through a random intercept in a glmer model. Now I want to test the spatial autocorrelation in the residuals but I’m not sure if the test procedure based on the residual is the same as for the fixed-effect models since now I have time dependency. Nov 10, 2018 · You should try many of them and keep the best model. In this case the spatial autocorrelation in considered as continous and could be approximated by a global function. Second, you could go with the package mgcv, and add a bivariate spline (spatial coordinates) to your model. This way, you could capture a spatial pattern and even map it. Jan 7, 2016 · Linear mixed-effect model without repeated measurements. The OLS model indicated that additional modeling components are necessary to account for individual-level clustering and residual autocorrelation. Linear mixed-effect models allow for non-independence and clustering by describing both between and within individual differences. Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2). Generalized additive models were flrst proposed by Hastie and Tibshirani (1986, 1990). These models assume that the mean of the response variable depends on an additive pre-dictor through a link function. Like generalized linear models (GLMs), generalized additive models permit the response probability distribution to be any member of the ...There is spatial autocorrelation in the data which has been identified using a variogram and Moran's I. The problem is I tried to run a lme model, with a random effect of the State that district is within: mod.cor<-lme(FLkm ~ Monsoon.Precip + Monsoon.Temp,correlation=corGaus(form=~x+y,nugget=TRUE), data=NE1, random = ~1|State)What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals. There is spatial autocorrelation in the data which has been identified using a variogram and Moran's I. The problem is I tried to run a lme model, with a random effect of the State that district is within: mod.cor<-lme(FLkm ~ Monsoon.Precip + Monsoon.Temp,correlation=corGaus(form=~x+y,nugget=TRUE), data=NE1, random = ~1|State)a combination of both models (ARMA). random effects that model independence among observations from the same site using GAMMs. That is, in addition to changing the basis as with the nottem example, we can also add complexity to the model by incorporating an autocorrelation structure or mixed effects using the gamm() function in the mgcv packageModels all contained the same fixed effects, were compared using AIC, and were fitted by REML (to allow comparison of different correlation structures by AIC). I'm using the R package nlme and the gls function. Question 1. The GLS models' residuals still display almost identical cyclical patterns when plotted against time.I have a dataset of 12 days of diary data. I am trying to use lme to model the effect of sleep quality on stress, with random intercept effects of participant and random slope effect of sleep quality. I am not particularly interested in asking whether there was change over time from diaryday 1 to 12, just in accounting for the time variable. (1) this assumes the temporal pattern is the same across subjects; (2) because gamm() uses lme rather than lmer under the hood you have to specify the random effect as a separate argument. (You could also use the gamm4 package, which uses lmer under the hood.) You might want to allow for temporal autocorrelation. For example,Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2). 3.1 The nlme package. nlme is a package for fitting and comparing linear and nonlinear mixed effects models. It let’s you specify variance-covariance structures for the residuals and is well suited for repeated measure or longitudinal designs. Subject. Re: st: mixed effect model and autocorrelation. Date. Sat, 13 Oct 2007 12:00:33 +0200. Panel commands in Stata (note: only "S" capitalized!) usually accept unbalanced panels as input. -glamm- (remember the dashes!), which you can download from ssc (by typing: -ssc install gllamm-), allow for the option cluster, which at least partially ...An extension of the mixed-effects growth model that considers between-person differences in the within-subject variance and the autocorrelation. Stat Med. 2022 Feb 10;41 (3):471-482. doi: 10.1002/sim.9280.we use corCAR1, which implements a continuous-time first-order autocorrelation model (i.e. autocorrelation declines exponentially with time), because we have missing values in the data. The more standard discrete-time autocorrelation models (lme offers corAR1 for a first-order model and corARMA for a more general model) don’t work with ...Mixed-effect linear models. Whereas the classic linear model with n observational units and p predictors has the vectorized form. where and are design matrices that jointly represent the set of predictors. Random effects models include only an intercept as the fixed effect and a defined set of random effects.We conducted a small simulation study to investigate whether an extension of the mixed-effect model that considers between-person differences in the Level 1 variance and the autocorrelation (i.e., the E-MELS) yields more precise forecasts than a standard longitudinal mixed-effect model.Linear Mixed Effects Models. Linear Mixed Effects models are used for regression analyses involving dependent data. Such data arise when working with longitudinal and other study designs in which multiple observations are made on each subject. Some specific linear mixed effects models are. Random intercepts models, where all responses in a ...Apr 12, 2018 · Here's a mixed model without autocorrelation included: cmod_lme <- lme(GS.NEE ~ cYear, data=mc2, method="REML", random = ~ 1 + cYear | Site) and you can explore the autocorrelation by using plot(ACF(cmod_lme)) . Zuur et al. in \"Mixed Effects Models and Extensions in Ecology with R\" makes the point that fitting any temporal autocorrelation structure is usually far more important than getting the perfect structure. Start with AR1 and try more complicated structures if that seems insufficient. This is what we refer to as “random factors” and so we arrive at mixed effects models. Ta-daa! 6. Mixed effects models. A mixed model is a good choice here: it will allow us to use all the data we have (higher sample size) and account for the correlations between data coming from the sites and mountain ranges. Mar 15, 2022 · A random effects model that contains only random intercepts, which is the most common use of mixed effect modeling in randomized trials, assumes that the responses within subject are exchangeable. This can be seen from the statement of the linear mixed effects model with random intercepts. Sep 16, 2018 · Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ... Abstract. The ‘DHARMa’ package uses a simulation-based approach to create readily interpretable scaled (quantile) residuals for fitted (generalized) linear mixed models. Currently supported are linear and generalized linear (mixed) models from ‘lme4’ (classes ‘lmerMod’, ‘glmerMod’), ‘glmmTMB’, ‘GLMMadaptive’ and ‘spaMM ...we use corCAR1, which implements a continuous-time first-order autocorrelation model (i.e. autocorrelation declines exponentially with time), because we have missing values in the data. The more standard discrete-time autocorrelation models (lme offers corAR1 for a first-order model and corARMA for a more general model) don’t work with ...

6 Linear mixed-effects models with one random factor. 6.1 Learning objectives; 6.2 When, and why, would you want to replace conventional analyses with linear mixed-effects modeling? 6.3 Example: Independent-samples \(t\)-test on multi-level data. 6.3.1 When is a random-intercepts model appropriate? . Wells fargopercent27s closest to me

mixed effect model autocorrelation

Dec 12, 2022 · It is a linear mixed model, with log-transformed OM regressed on marsh site (categorical), marsh type (categorical), soil category (categorical), depth (numerical, based on ordinal depth ranges), and the interaction between depth and marsh type; marsh site effects are modeled as random, on which the ICAR spatial autocorrelation structure is ... GLM, generalized linear model; RIS, random intercepts and slopes; LME, linear mixed-effects model; CAR, conditional autoregressive priors. To reduce the number of explanatory variables in the most computationally demanding of the analyses accounting for spatial autocorrelation, an initial Bayesian CAR analysis was conducted using the CARBayes ...Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2). For a linear mixed-effects model (LMM), as fit by lmer, this integral can be evaluated exactly. For a GLMM the integral must be approximated. For a GLMM the integral must be approximated. The most reliable approximation for GLMMs is adaptive Gauss-Hermite quadrature, at present implemented only for models with a single scalar random effect.c (Claudia Czado, TU Munich) – 11 – Likelihood Inference for LMM: 1) Estimation of β and γ for known G and R Estimation of β: Using (5), we have as MLE or weighted LSE of βRecently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...This example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement. Models all contained the same fixed effects, were compared using AIC, and were fitted by REML (to allow comparison of different correlation structures by AIC). I'm using the R package nlme and the gls function. Question 1. The GLS models' residuals still display almost identical cyclical patterns when plotted against time.A random effects model that contains only random intercepts, which is the most common use of mixed effect modeling in randomized trials, assumes that the responses within subject are exchangeable. This can be seen from the statement of the linear mixed effects model with random intercepts.Gamma mixed effects models using the Gamma() or Gamma.fam() family object. Linear mixed effects models with right and left censored data using the censored.normal() family object. Users may also specify their own log-density function for the repeated measurements response variable, and the internal algorithms will take care of the optimization. Oct 11, 2022 · The code below shows how the random effects (intercepts) of mixed models without autocorrelation terms can be extracted and plotted. However, this approach does not work when modelling autocorrelation in glmmTMB. Use reproducible example data from this question: glmmTMB with autocorrelation of irregular times GLM, generalized linear model; RIS, random intercepts and slopes; LME, linear mixed-effects model; CAR, conditional autoregressive priors. To reduce the number of explanatory variables in the most computationally demanding of the analyses accounting for spatial autocorrelation, an initial Bayesian CAR analysis was conducted using the CARBayes ...GLMMs. In principle, we simply define some kind of correlation structure on the random-effects variance-covariance matrix of the latent variables; there is not a particularly strong distinction between a correlation structure on the observation-level random effects and one on some other grouping structure (e.g., if there were a random effect of year (with multiple measurements within each year ...in nlme, it is possible to specify the variance-covariance matrix for the random effects (e.g. an AR (1)); it is not possible in lme4. Now, lme4 can easily handle very huge number of random effects (hence, number of individuals in a given study) thanks to its C part and the use of sparse matrices. The nlme package has somewhat been superseded ... .

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